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Gout (also known as podagra when it involves the big toe) is usually characterized by recurrent attacks of inflammatory arthritis—a red, tender, hot, and swollen joint. Pain typically comes on rapidly in less than twelve hours. The joint at the base of the big toe is affected in about half of cases. It may also result in tophi, kidney stones, or urate nephropathy.<br/><br/> James Gillray (13 August 1756 or 1757 – 1 June 1815) was an English caricaturist and printmaker famous for his etched political and social satires, mainly published between 1792 and 1810.
Tharangambadi, formerly Tranquebar, is a town in the Nagapattinam district of the Indian state of Tamil Nadu. It lies 15 kilometres (9.3 mi) north of Karaikal, near the mouth of a distributary of the Kaveri River.<br/><br/> It was a Danish colony from 1620 to 1845, and in Danish it is still known as Trankebar.
Václav Hollar (13 July 1607 – 25 March 1677), was a Bohemian etcher, known in England as Wenceslaus or Wenceslas and in Germany as Wenzel Hollar.<br/><br/> He was born in Prague, and died in London, being buried at St Margaret's Church, Westminster.
Václav Hollar (13 July 1607 – 25 March 1677), was a Bohemian etcher, known in England as Wenceslaus or Wenceslas and in Germany as Wenzel Hollar.<br/><br/> He was born in Prague, and died in London, being buried at St Margaret's Church, Westminster.
Hasekura Rokuemon Tsunenaga was a Japanese samurai and retainer of Date Masamune, the daimyo of Sendai.<br/><br/> In the years 1613 - 1620, Hasekura headed a diplomatic mission to the Vatican in Rome, traveling through New Spain (arriving in Acapulco and departing from Veracruz) and visiting various ports-of-call in Europe. This historic mission is called the Keicho Embassy, and follows the Tensho embassy of 1582. On the return trip, Hasekura and his companions re-traced their route across Mexico in 1619, sailing from Acapulco for Manila, and then sailing north to Japan in 1620. He is conventionally considered the first Japanese ambassador in the Americas and in Europe.<br/><br/> Although Hasekura's embassy was cordially received in Europe, it happened at a time when Japan was moving toward the suppression of Christianity. European monarchs such as the King of Spain thus refused the trade agreements Hasekura had been seeking. Hasekura returned to Japan in 1620 and died of illness a year later, his embassy seemingly ending with few results in an increasingly isolationist Japan.
Hormuz Island (also spelled Hormoz) is an Iranian island in the Persian Gulf. It is located in the Straits of Hormuz and is part of the Hormozgān Province. It has an area of 42 km² (16 square miles).<br/><br/> Hormuz Island was once part of the Portuguese Empire. The island was conquered by the Portuguese explorer Afonso de Albuquerque in the Capture of Ormuz. There is a historic Portuguese fortress on Hormuz Island, the Fort of Our Lady of the Conception. The island was then captured by a combined Anglo-Persian force in 1622 in the Capture of Ormuz.