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The Madrid Skylitzes is a heavily illustrated illuminated manuscript of the Synopsis of Histories by John Skylitzes, which covers the reigns of the Byzantine emperors from the death of Nicephorus I in 811 to the deposition of Michael IV in 1057. The manuscript was produced in Sicily in the 12th century, and is now at the Biblioteca Nacional de Espana in Madrid, so is known as the Madrid Skylitzes.