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Fabriano in central Italy was the first European centre of paper-making, developed after 1296 CE. Miliani also introduced the watermark technique. The technology for pulping and pressing paper in this 15th century factory was not dissimilar to Chinese paper mills some 16 centuries earlier.
The music of Egypt has been an integral part of Egyptian culture since ancient times. The ancient Egyptians credited one of their Gods Thoth with the invention of music, which Osiris in turn used as part of his effort to civilize the world.<br/><br/>

The earliest material and representational evidence of Egyptian musical instruments dates to the Predynastic period, but the evidence is more securely attested in the Old Kingdom when harps, flutes and double clarinets were played. Percussion instruments, lyres and lutes were added to orchestras by the Middle Kingdom. Cymbals frequently accompanied music and dance, much as they still do in Egypt today.<br/><br/>

Egyptian folk music, including the traditional Sufi dhikr rituals, are the closest contemporary music genre to ancient Egyptian music, having preserved many of its features, rhythms and instruments.
The Edwin Smith papyrus, the world's oldest surviving surgical document. Written in hieratic script in ancient Egypt around 1600 BCE, the text describes anatomical observations and the examination, diagnosis, treatment, and prognosis of 48 types of medical problems in exquisite detail. Plate 6 and 7 of the papyrus, pictured here, discuss facial trauma.